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By addressing the fundamental mechanisms underlying bilirubin metabolism, researchers and clinicians can develop more effective strategies to prevent and treat gallstone, reducing associated complications and enhancing overall health

A classic example of diet-induced gut dysbiosis was recorded in the early 70s, where individuals from southern India who migrated to the United Kingdom in the 1970s frequently suffered from severe vitamin B12 deficiency (Britt et al., 1970, 1971

Two major signaling pathways, nuclear factor erythroid 2-related factor 2 (NRF2) and glutathione peroxidase 4 (GPX4), play important roles in ferroptosis

More human data are needed